New article published by Research Center for Immunodeficiencies 🔸Title An Overview of Early Genetic Predictors of IgA Deficiency 🔸Journal: Expert Review of Molecular Diagnostics 🔸IF: 3.9 🔸Year: 2024 🌀Article Highlights 🔹Immunoglobulin A deficiency is the most frequent type of IEI. 🔹To date, the exact pathogenesis of IgA deficiency has not been clearly understood, however several HLA haplotypes and genes are found to be involved in the development of IgA deficiency. 🔹The most commonly found HLA haplotypes among IgA-deficient individuals include HLA-B * 08- DRB1 × 0301-DQB1 × 02, HLA-B * 14-DRB1 × 0102-DQB1 × 05 and HLA-B * 44-DRB1 × 0701. 🔹Defects in genes encoding factors involved in various steps of B-cell development, IgA class switch recombination (CSR), synthesis and secretion along with long-term survival of IgA switched memory B cells and plasma cells are associated with the development of IgA deficiency. 🌀Source https://doi.org/10.1080/14737159.2024.2385521 @RCIDtums