Study the frequency of fluoroquinolone-resistant genes (Fu-Ru) in Staphylococcus aureus strains isolated from Covid-19 patients Study the frequency of fluoroquinolone-resistant genes (Fu-Ru) in Staphylococcus aureus strains isolated from Covid-19 patients Abstract During the corona pandemic, there was a significant increase in the excessive use of antibiotics among patients. This unscheduled use of antibiotics led to the increase of antibiotic resistant strains of different bacteria. The purpose of this research is to investigate the prevalence of resistance to fluoroquinolones in Staphylococcal strains isolated from covid-19 patients. The disc diffusion test was performed using the Kirby-Bauer method. Fu-Ru enzymes produced by a double-disk synergy (DDS) test and using Ciprofloxatin (30 µg/ml) and Ceftazidime plus Nalidixic Acid (30+10 µg/ml) was determined. Fu-Ru gene were detected in the isolates using PCR. Approximately 87 S. aureus isolates from different clinical specimens, including urine (1%), wounds (3%), bronchoalveolar lavage (71%), blood (20%), and cerebrospinal fluid (CSF) (5%). All isolates were resistant to Ciprofloxatin, most of which had MICs between 32 and 256 µg/ml, and only two isolates with high resistance of 512 µg/ml were identified. A significant relationship was observed between the presence of Fu-Ru gene and the MIC results of Ciprofloxatin.  For Fu-Ru the frequency of this gene between isolates were 80 percent. The results of current research confirmed that the Covid-19 pandemic cause increase in the resistance of Staphylococcus aureus to fluoroquinolones antibiotics. Keywords: Antibiotic resistance, Fluoroquinolones, Covid-19 pandemic, Fu-Ru gene, PCR مقاله اورجینال، ریوایز مینور، اکسپتنس حداکثر تا سه هفته تا یک ماه برای مجله ای با مشخصات زیر Journal:  Scopus (q4) نویسنده اول : ۱۳ نویسنده دوم: ۷ نویسنده سوم: ۶ نویسنده چهارم: ۵ نویسنده پنجم: ۵ نویسنده ششم: واگذار شد نویسنده هفتم: واگذار شد نویسنده مسئول: قیمت هرکدام از جایگاه ها به اضافه ۵ تومان