Reverse Signaling by MHC-I Molecules in Immune and Non-Immune Cell Types

"The Alternative Role of MHC-I as Signaling Molecules and Their Structure

Besides their role in antigen presentation for T cell activation, both MHC-I and MHC-II molecules are involved in reverse signaling, meaning that ligation of the MHC molecule leads to signal-transduction and cell regulatory effects in the APC (3). In this review we will focus on reverse MHC-I signaling; given the ample literature available across different cell types, its importance for medical outcomes in transplantation patients and its potential role regulating immune responses against infection and malignancies."

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.605958/full